Bipolar Disorder: Recent submissions
Now showing items 1-20 of 38
-
Cognitive Remediation in Bipolar (CRiB2): study protocol for a randomised controlled trial assessing efficacy and mechanisms of cognitive remediation therapy compared to treatment as usual
(2023-11)A substantial proportion of people with bipolar disorder (BD) experience persistent cognitive difficulties associated with impairments in psychosocial functioning and a poorer disorder course. Emerging evidence suggests ... -
Protocol for a systematic review and meta-analysis of coordinate-based network mapping of brain structure in bipolar disorder across the lifespan
(2023-10)Background: Studies about brain structure in bipolar disorder have reported conflicting findings. These findings may be explained by the high degree of heterogeneity within bipolar disorder, especially if structural ... -
The IBER study: a feasibility randomised controlled trial of Imagery Based Emotion Regulation for the treatment of anxiety in bipolar disorder
(2022-11)Background: Intrusive mental imagery is associated with anxiety and mood instability within bipolar disorder and therefore represents a novel treatment target. Imagery Based Emotion Regulation (IBER) is a brief structured ... -
Psychosocial markers of age at onset in bipolar disorder: a machine learning approach
(2022-07)Bipolar disorder is a chronic and severe mental health disorder. Early stratification of individuals into subgroups based on age at onset (AAO) has the potential to inform diagnosis and early intervention. Yet, the ... -
Mental health prior to and during the COVID-19 pandemic in individuals with bipolar disorder: Insights from prospective longitudinal data
(2022-03)Many studies have examined the impact of COVID-19 on the mental health of the public, but few have focused on individuals with existing severe mental illness with longitudinal data before and during the pandemic. Aims: To ... -
An Overview of Sleep and Circadian Rhythms in Bipolar Disorder
(2022-03)Since the conception of bipolar disorder (BD) as a psychiatric condition, sleep and circadian rhythm disruptions have been cardinal symptoms of the disorder. Current nosologies recognise this and such disruptions form part ... -
Characterizing Affective Variability in Bipolar Disorder and Borderline Personality Disorder, and the Effects of Lithium, Using a Generative Model of Affect
(2022-02)The affective variability of Bipolar Disorder (BD) is thought to qualitatively differ from that of Borderline Personality Disorder (BPD), with changes in affect persisting for longer in BD. However, quantitative studies ... -
The costs of bipolar disorder in the United Kingdom
(2021-09)Objectives: To estimate the individual cost and population-level economic burden of Bipolar Disorder (BD), and explore the impact of clinical and sociodemographic factors on costs in the United Kingdom. Methods: Annual ... -
Effect of lithium on circadian rhythm in bipolar disorder: A systematic review and meta-analysis
(2021-03)Circadian rhythm disruption is commonly reported in patients with bipolar disorder. Lithium has been suggested to have effects on the circadian clock, the biological basis of the circadian rhythm. The objective of the ... -
Study protocol for a randomised placebo-controlled trial of pramipexole in addition to mood stabilisers for patients with treatment resistant bipolar depression (the PAX-BD study)
(2021-07)Treatment Resistant Bipolar Depression (TRBD) is a major contributor to the burden of disease associated with Bipolar Disorder (BD). Treatment options for people experiencing bipolar depression are limited to three ... -
Behavioural sleep and circadian rhythm interventions in bipolar disorder: a systematic review of randomised controlled trials
(2021-07)Sleep and circadian rhythm disruptions are prominent symptoms of bipolar disorder (BD) and potential targets for adjunctive behavioural intervention. The aim of this systematic review was to appraise evidence from ... -
Demystifying the pathway of assessment and treatment for bipolar disorder – utilising co-production and algorithms to personalise the approach
(2021-06)Aims: To develop an evidence based, patient centred treatment pathway for people experiencing symptoms of bipolar disorder (BD), modifiable to include local resources. The approach and resources collated here will ... -
Functional Connectivity between Task-Positive Networks and the Left Precuneus as a Biomarker of Response to Lamotrigine in Bipolar Depression: A Pilot Study
(2021-06)Treatment of bipolar depression poses a significant clinical challenge. Lamotrigine is one of a few efficacious drugs, however, it needs to be titrated very slowly and response can only be assessed after 10–12 weeks. With ... -
Modelling paralinguistic properties in conversational speech to detect bipolar disorder and borderline personality disorder
(2021-02)Bipolar disorder (BD) and borderline personality disorder (BPD) are two chronic mental health conditions that clinicians find challenging to distinguish based on clinical interviews, due to their overlapping symptoms. In ... -
Lithium modulates striatal reward anticipation and prediction error coding in healthy volunteers
(2020-10)Lithium is one of the most effective mood-stabilizing medications in bipolar disorder. This study was designed to test whether lithium administration may stabilize mood via effects on reward processing. It was hypothesized ... -
Incidence of Parkinson’s disease, dementia, cerebrovascular disease and stroke in bipolar disorder compared to other psychiatric disorders: An electronic health records network study of 66 million people
(2020-10)Bipolar disorder has been associated with an increased risk for neurodegenerative diseases, but uncertainties remain. The risk relative to other psychiatric disorders is not established. Methods We used a federated ... -
Adjunctive Psychotherapy for Bipolar Disorder A Systematic Review and Component Network Meta-analysis
(2020-10)Importance Several psychotherapy protocols have been evaluated as adjuncts to pharmacotherapy for patients with bipolar disorder, but little is known about their comparative effectiveness. Objective To use systematic ... -
A phase 2a randomised, double-blind, placebo-controlled, parallel-group, add-on clinical trial of ebselen (SPI-1005) as a novel treatment for mania or hypomania.
(2020-09)Rationale Lithium is an effective prophylactic and anti-manic treatment in bipolar disorder; however, its use is declining through perceived poor tolerance and toxicity. Lithium inhibits inositol monophosphatase (IMPase), ... -
Learning to Detect Bipolar Disorder and Borderline Personality Disorder with Language and Speech in Non-Clinical Interviews
(2020-08)Bipolar disorder (BD) and borderline personality disorder (BPD) are both chronic psychiatric disorders. However, their overlapping symptoms and common comorbidity make it challenging for the clinicians to distinguish ... -
What we learn about bipolar disorder from large-scaleneuroimaging: Findings and future directions from theENIGMA Bipolar Disorder Working Group
(2020-06)MRI-derived brain measures offer a link between genes, the environment and behav-ior and have been widely studied in bipolar disorder (BD). However, many neuroimag-ing studies of BD have been underpowered, leading to varied ...
