Depressive Disorders: Recent submissions
Now showing items 21-40 of 111
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Sleep deprivation as a treatment for major depressive episodes: A systematic review and meta-analysis
(2022-05)Sleep deprivation, alone or in combination with pharmacological treatment and as part of a chronotherapy package, is of potential use for people with major depressive episodes, however the evidence base is still conflicting. ... -
Efficacy and acceptability of next step treatment strategies in adults with treatment-resistant major depressive disorder: protocol for systematic review and network meta-analysis
(2022-04)For major depression, a one-size-fits-all treatment does not exist. Patients enter a ‘trial-and-change’ algorithm in which effective therapies are subsequently applied. Unfortunately, an empirically based order of treatments ... -
Effects of escitalopram therapy on functional brain controllability in major depressive disorder
(2022-04)Antidepressant drugs are the mainstay of treatment for patients with major depressive disorders (MDD). Given the critical role of the underlying neural control mechanism in the physiopathology of depression, this study ... -
Catechol-O-methyltransferase activity does not influence emotional processing in men
(2022-04)Background: Catechol-O-methyltransferase (COMT) regulates cortical dopaminergic transmission and prefrontal-dependent cognitive function. However, its role in other cognitive processes, including emotional processing, is ... -
Clinical- and cost-effectiveness of a technology-supported and solution-focused intervention (DIALOG+) in treatment of patients with chronic depression—study protocol for a multi-site, cluster randomised controlled trial [TACK]
(2022-03)Many with an acute depressive disorder go on to develop chronic depression, despite ongoing care. There are few specifically designed interventions to treat chronic depression. DIALOG+, a technology-assisted intervention ... -
A dose–effect network meta-analysis model with application in antidepressants using restricted cubic splines
(2022-02)Network meta-analysis has been used to answer a range of clinical questions about the preferred intervention for a given condition. Although the effectiveness and safety of pharmacological agents depend on the dose ... -
Symptom Dynamics and Attention in Depression: Fatigue and Low Positive Affect are Associated With Reduced Orienting Efficiency
(2022-02)Depression is a heterogeneous mental disorder involving a complex interplay between potential etiological and maintenance factors. The current study examined how depression heterogeneity is related to attentional ... -
Development and validation of a meta-learner for combining statistical and machine learning prediction models in individuals with depression
(2022-05)The debate of whether machine learning models offer advantages over standard statistical methods when making predictions is ongoing. We discuss the use of a meta-learner model combining both approaches as an alternative. ... -
Pramipexole Enhances Reward Learning by Preserving Value Estimates
(2022-01)Background: Dopamine D2-like receptor agonists show promise as treatments for depression. They are thought to act by altering how individuals learn from rewarding experiences. However, the nature of these reward learning ... -
Dose–effect meta-analysis for psychopharmacological interventions using randomised data
(2022-01)Objective The current practice in meta-analysis of the effects of psychopharmacological interventions ignors the administered dose or restricts the analysis in a dose range. This may introduce unnecessary uncertainty and ... -
Selective publication of antidepressant trials and its influence on apparent efficacy: Updated comparisons and meta-analyses of newer versus older trials
(2022-01)Valid assessment of drug efficacy and safety requires an evidence base free of reporting bias. Using trial reports in Food and Drug Administration (FDA) drug approval packages as a gold standard, we previously found that ... -
Treatment-resistant depression: therapeutic options when first-line treatments fail
(2021-12)The Cochrane review by Davies et al aimed to address the lack of clarity on the risks and benefits of switching and augmentation strategies in the pharmacological treatment of treatment-resistant depression in adults who ... -
No antidepressant-like acute effects of bright light on emotional information processing in healthy volunteers
(2021-11)Rationale: Bright light treatment (BLT) is an efficacious antidepressant intervention, but its mechanism of action is not well understood. Antidepressant drugs acutely affect how emotional information is processed, pushing ... -
Characterising the severity of treatment resistance in unipolar and bipolar depression
(2021-10)Treatment-resistant depression (TRD) is classically defined according to the number of suboptimal antidepressant responses experienced, but multidimensional assessments of TRD are emerging and may confer some advantages. ... -
Initial treatment choices to achieve sustained response in major depression: a systematic review and network meta-analysis
(2021-10)Major depression is often a relapsing disorder. It is therefore important to start its treatment with therapies that maximize the chance of not only getting the patients well but also keeping them well. We examined the ... -
Resting state functional connectivity patterns as biomarkers of treatment response to escitalopram in patients with major depressive disorder
(2021-09)With no available response biomarkers, matching an appropriate antidepressant to an individual can be a lengthy process. Improving understanding of processes underlying treatment responsivity in depression is crucial for ... -
An Experimental Medicine Investigation of the Effects of Subacute Pramipexole Treatment on Emotional Information Processing in Healthy Volunteers
(2021-08)Treatment with the dopamine D2/D3 receptor agonist pramipexole has demonstrated promising clinical effects in patients with depression. However, the mechanisms through which pramipexole might alleviate depressive symptoms ... -
The knowns and unknowns of SSRI treatment in young people with depression and anxiety: efficacy, predictors, and mechanisms of action
(2021-08)The use of SSRIs for the treatment of depression and anxiety in young people is increasing. However, the effects of SSRIs in adolescence, a time when there are substantial changes in neural, cognitive, and social functioning, ... -
An Experimental Medicine Investigation of the Effects of Subacute Pramipexole Treatment on Emotional Information Processing in Healthy Volunteers
(2021-08)Treatment with the dopamine D2/D3 receptor agonist pramipexole has demonstrated promising clinical effects in patients with depression. However, the mechanisms through which pramipexole might alleviate depressive symptoms ... -
A Computational View on the Nature of Reward and Value in Anhedonia
(2021-08)Anhedonia—a common feature of depression—encompasses a reduction in the subjective experience and anticipation of rewarding events, and a reduction in the motivation to seek out such events. The presence of anhedonia often ...