Browsing Depressive Disorders by Subject "Depressive Disorders"
Now showing items 1-20 of 89
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Accuracy in recognising happy facial expressions is associated with antidepressant response to a NOP receptor antagonist but not placebo treatment
(2021-10)Background: Clinical trials with putative antidepressants can be difficult to execute as it can take up to 8 weeks before differences emerge between drug and placebo, and long expensive trials often fail. Implementation ... -
Acute neural effects of fluoxetine on emotional regulation in depressed adolescents
(2022-05)Adolescent major depressive disorder (MDD) is associated with disrupted processing of emotional stimuli and difficulties in cognitive reappraisal. Little is known however about how current pharmacotherapies act to modulate ... -
Addressing concerns about smoking cessation and mental health: theoretical review and practical guide for healthcare professionals
(2020-07)Smoking rates in people with depression and anxiety are twice as high as in the general population, even though people with depression and anxiety are motivated to stop smoking. Most healthcare professionals are aware that ... -
Affective bias as a rational response to the statistics of rewards and punishments
(2017-10)Affective bias, the tendency to differentially prioritise the processing of negative relative to positive events, is commonly observed in clinical and non-clinical populations. However, why such biases develop is not known. ... -
Antidepressants might work for people with major depression: where do we go from here? (Comment)
(2018-06)The publication of our updated network meta-analysis about antidepressants for the acute treatment of major depression has generated a wide discussion in newspapers, social media, and scientific journals. Based on 522 ... -
Antidepressants plus benzodiazepines in major depressive disorder: a clinical dilemma with no recent answers from research
(2020-10)Comorbid anxiety symptoms are common in depression, and adding benzodiazepines to antidepressant treatment may seem a rational clinical solution. Benzodiazepines also have potential to reduce the initial anxiety that may ... -
Associations between statin use and suicidality, depression, anxiety, and seizures: a Swedish total-population cohort study
(2020-11)Background Statins have shown both protective and adverse associations with neuropsychiatric outcomes. We aimed to examine the possible associations between statins and suicidality, depression, anxiety, and seizures. M ... -
Characterising the severity of treatment resistance in unipolar and bipolar depression
(2021-10)Treatment-resistant depression (TRD) is classically defined according to the number of suboptimal antidepressant responses experienced, but multidimensional assessments of TRD are emerging and may confer some advantages. ... -
Characterization of the central nervous system penetrant and selective purine P2X7 receptor antagonist JNJ-54175446 in patients with major depressive disorder
(2023-07)JNJ-54175446 is a selective purine P2X7 receptor (P2X7R) antagonist that attenuates microglial IL-1β/IL-18 release. In healthy volunteers, JNJ-54175446 suppressed peripheral interleukin (IL)-1β release, and attenuated ... -
Clinical- and cost-effectiveness of a technology-supported and solution-focused intervention (DIALOG+) in treatment of patients with chronic depression—study protocol for a multi-site, cluster randomised controlled trial [TACK]
(2022-03)Many with an acute depressive disorder go on to develop chronic depression, despite ongoing care. There are few specifically designed interventions to treat chronic depression. DIALOG+, a technology-assisted intervention ... -
Cognitive neuropsychological theory of antidepressant action: a modern-day approach to depression and its treatment
(2020-01)Depression is a leading cause of disability worldwide and improving its treatment is a core research priority for future programmes. A change in the view of psychological and biological processes, from seeing them as ... -
Cognitive predictors of stress-induced mood malleability in depression
(2023-09)Basic attentional control, negative biases in attention and interpretation, and rumination are all cognitive processes associated with depression; however, less is known about their predictive role in depressive mood ... -
Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis
(2018-04)BACKGROUND Major depressive disorder is one of the most common, burdensome, and costly psychiatric disorders worldwide in adults. Pharmacological and non-pharmacological treatments are available; however, because of ... -
Comparative efficacy and acceptability of antidepressants in the long-term treatment of major depression: protocol for a systematic review and networkmeta-analysis
(2019-05)Introduction: Pharmacotherapy plays an important role in the treatment of major depression. At the initiation of antidepressant treatment, both improvement of symptoms in the short term and relapse prevention in the long ... -
A Computational View on the Nature of Reward and Value in Anhedonia
(2021-08)Anhedonia—a common feature of depression—encompasses a reduction in the subjective experience and anticipation of rewarding events, and a reduction in the motivation to seek out such events. The presence of anhedonia often ... -
Development and validation of a meta-learner for combining statistical and machine learning prediction models in individuals with depression
(2022-05)The debate of whether machine learning models offer advantages over standard statistical methods when making predictions is ongoing. We discuss the use of a meta-learner model combining both approaches as an alternative. ... -
A Dissociation of the Acute Effects of Bupropion on Positive Emotional Processing and Reward Processing in Healthy Volunteers
(2018-10)Background: Previous research indicates that antidepressants can restore the balance between negative and positive emotional processing early in treatment, indicating a role of this effect in later mood improvement. However, ... -
A dose-effect network meta-analysis model: an application in antidepressants
(2021-04)Network meta-analysis (NMA) has been used to answer a range of clinical questions about the preferable intervention for a given condition. Although the effectiveness and safety of pharmacological agents depend on the dose ... -
Effect of acute citalopram on self-referential emotional processing and social cognition in healthy volunteers
(2020-10)Background Depression is characterised by negative views of the self. Antidepressant treatment may remediate negative self-schema through increasing processing of positive information about the self. Changes in affective ... -
Effect of selective serotonin reuptake inhibitor treatment following diagnosis of depression on suicidal behaviour risk: a target trial emulation
(2023-07)There is concern regarding the impact of selective serotonin reuptake inhibitors (SSRIs) on suicidal behaviour. Using the target trial framework, we investigated the effect on suicidal behaviour of SSRI treatment following ...