Conditions, Lifestyle Factors & Interventions: Recent submissions
Now showing items 721-740 of 910
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Variation in spend on young mental health across Clinical Commissioning Groups in England: a cross-sectional observational study
(2019-08)Objectives To investigate whether the rate of spend on child and adolescent mental health is influenced by demand for other competing services in local commissioning decisions. Design Analysis of spend data by Clinical ... -
The Salt Swap intervention to reduce salt intake in people with high blood pressure: protocol for a feasibility randomised controlled trial
(2019-10)Background: High salt intake is a risk factor for hypertension and cardiovascular disease. Reducing salt intake has been shown to reduce blood pressure. Despite population-level interventions, including product reformulation ... -
Self-reported depression symptoms in haemodialysis patients: Bi-factor structures of two common measures and their association with clinical factors
(2018-08)Objective: To validate the factor structure of two common self-report depression tools in a large sample of haemodialysis (HD) patients and to examine their demographic and clinical correlates, including urine output, ... -
Value of monitoring negative emotional bias in primary care in England for personalised antidepressant treatment: a modelling study
(2019-11)Depressed patients often focus on negative life events. Effective antidepressant therapy reverses this negative emotional bias (NEB) within 1 week. Clinical therapeutic effect usually requires 4–6 weeks. The value of ... -
Premembering Experience: A Hierarchy of Time-Scales for Proactive Attention
(2019-10)Memories are about the past, but they serve the future. Memory research often emphasizes the former aspect: focusing on the functions that re-constitute (re-member) experience and elucidating the various types of memories ... -
Treatment for depression comorbid with dementia
(2019-11)Depression is a common comorbidity in dementia. Randomised controlled studies of antidepressants do not show a significant improvement in depressive symptoms in patients with comorbid dementia and are known to lead to an ... -
Ketamine for suicidal ideation in adults with psychiatric disorders: A systematic review and meta-analysis of treatment trials
(2019-07)Ketamine may reduce suicidal ideation in treatment-resistant depression. But it is not known how quickly this occurs and how long it persists. We undertook a systematic review and meta-analysis to determine the short and ... -
Prevalence of Non-Affective Psychoses in Individuals with Autism Spectrum Disorders: A Systematic Review
(2019-08)Autism spectrum disorders (ASD) and non-affective psychoses such as schizophrenia are commonly acknowledged as discrete entities. Previous research has revealed evidence of high comorbidity between these conditions, but ... -
The genomic basis of mood instability: identification of 46 loci in 363,705 UK Biobank participants, genetic correlation with psychiatric disorders, and association with gene expression and function
(2019)Genome-wide association studies (GWAS) of psychiatric phenotypes have tended to focus on categorical diagnoses, but to understand the biology of mental illness it may be more useful to study traits which cut across traditional ... -
Is adjunctive CBT really effective for schizophrenia?
(2019-09)Although antipsychotic medication remains the mainstay of treatment for schizophrenia, medications alone are not always successful. Cognitive– behavioural therapy (CBT) is recommended as an adjunct to pharmacological ... -
Moderators and mediators of outcome in treatments for anorexia nervosa and bulimia nervosa in adolescents: A systematic review of randomized controlled trials
(2019-09)Objective:To critically appraise papers reporting on moderators and mediators of recommended psychological treatments for anorexia nervosa (AN) and bulimia nervosa (BN) in adolescents. Method:A systematic search of databases ... -
Characteristics of people with pressure ulcers using one year's routinely collected data in a defined diverse community
(2019-09)Objective:To determine if meaningful patient characteristics pertaining to pressure ulcers (PU) can be derived from routinely collected community health data. Methods: A retrospective cohort analysis of records was carried ... -
A Path Signature Approach for Speech Emotion Recognition
(2019-09)Automatic speech emotion recognition (SER) remains a difficult task within human-computer interaction, despite increasing interest in the research community. One key challenge is how to effectively integrate short-term ... -
Smoking and the risk for bipolar disorder: evidence from a bidirectional Mendelian randomisation study
(2019-09)Background:There is increasing evidence that smoking is a risk factor for severe mental illness, including bipolar disorder. Conversely, patients with bipolar disorder might smoke more (often) as a result of the psychiatric ... -
The weeks before 100 persecutory delusions: the presence of many potential contributory causal factors
(2019-09)Background:The period before the formation of a persecutory delusion may provide causal insights. Patient accounts are invaluable in informing this understanding. Aims:To inform the understanding of delusion formation, ... -
The comments of voices on the appearance of patients with psychosis: ‘the voices tell me that I am ugly’
(2019-09)Background:There are high rates of obesity and low self-esteem in patients with psychosis. The occurrence of negative voice content directly about appearance is therefore plausible. Derogatory comments about appearance are ... -
Automated virtual reality (VR) cognitive therapy for patients with psychosis: study protocol for a single-blind parallel group randomised controlled trial (gameChange).
(2019-08)Introduction Many patients with psychosis experience everyday social situations as anxiety-provoking. The fears can arise, for example, from paranoia, hallucinations, social anxiety or negative-self beliefs. The fears lead ... -
Exercise- and strategy-based physiotherapy-delivered intervention for preventing repeat falls in people with Parkinson's: the PDSAFE RCT.
(2019-07)BACKGROUND: People with Parkinson's disease are twice as likely to experience a fall as a healthy older person, often leading to debilitating effects on confidence, activity levels and quality of life. OBJECTIVE: To ... -
CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice
(2019-08)Neuroinflammation and microglial activation are significant processes in Alzheimer’s disease pathology. Recent genome-wide association studies have highlighted multiple immune-related genes in association with Alzheimer’s ... -
Best Methods of Communicating Clinical Trial Data to Improve Understanding of Treatments for Patients with Multiple Sclerosis
(2018-07)Background Patients’ understanding of treatment risks and benefits is a prerequisite for shared decision making. Yet, patients with multiple sclerosis (MS) do not accurately understand treatment information provided in ...