Conditions, Lifestyle Factors & Interventions: Recent submissions
Now showing items 621-640 of 910
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A single administration of ‘microbial’ D-alanine to healthy volunteers augments reaction to negative emotions: a comparison with D-serine
(2020-03)Background Activation of the glutamate N-methyl-D-Aspartate receptor (NMDAR) with its co-agonist D-serine has been shown to improve subjective mood in healthy volunteers. D-alanine is another potent NMDAR co-agonist which ... -
Subthalamic nucleus activity dynamics and limb movement prediction in Parkinson’s disease
(2020-02)Whilst exaggerated bursts of beta frequency band oscillatory synchronization in the subthalamic nucleus have been associated with motor impairment in Parkinson’s disease, a plausible mechanism linking the two phenomena has ... -
Association Between Neurological Disorders and Death by Suicide in Denmark
(2020-02)Importance Neurological disorders have been linked to suicide, but the risk across a broad spectrum of neurological disorders remains to be assessed. Objectives To examine whether people with neurological disorders die ... -
Advance care planning in patients referred to hospital for acute medical care
(2020-02)Advance care planning (ACP) is a voluntary process of discussion about future care between an individual and their care provider. ACP is a key focus of national policy as a means to improve patient centered care at the ... -
The side effect profile of Clozapine in real world data of three large mental hospitals
(2020-01)Objective: Mining the data contained within Electronic Health Records (EHRs) can potentially generate a greater understanding of medication effects in the real world, complementing what we know from Randomised control ... -
Development of the Ketamine Side Effect Tool
(2020-04)Background: Currently, no specific, systematic assessment tool for the monitoring and reporting of ketamine-related side effects exists. Our aim was to develop a comprehensive Ketamine Side Effect Tool (KSET) to capture ... -
Physical activity in a pandemic: A new treatment target for psychological therapy.
(2020-06)The COVID-19 pandemic and its management are placing significant new strains onpeople’s well-being, particularly those with pre-existing mental health conditions. Physicalactivity has been shown to improve mental as well ... -
Pharmacological interventions for self-harm in adults (Protocol)
(2020-07)This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the effects of psychosocial or pharmacological interventions for self‐harm (SH) compared to comparison types of care (e.g. ... -
Subjective cognitive complaints given in questionnaire: relationship with brain structure, cognitive performance and self-reported depressive symptoms in a 25-year retrospective cohort study
(2020-07)Subjective cognitive complaints are common but it is unclear whether they indicate an underlying pathological process or reflect affective symptoms. Method:800 community-dwelling older adults were drawn from the Whitehall ... -
The importance of different frailty domains in a population based sample in England
(2020-01)Background The aim was to estimate the prevalence of frailty and relative contribution of physical/balance, nutritive, cognitive and sensory frailty to important adverse health states (falls, physical activity levels, ... -
The True Colours Remote Symptom Monitoring System: A Decade of Evolution
(2020-01)The True Colours remote mood monitoring system was developed over a decade ago by researchers, psychiatrists, and software engineers at the University of Oxford to allow patients to report on a range of symptoms via text ... -
Prolonged Grief and Posttraumatic Stress Disorder Following the Loss of a Significant Other: An Investigation of Cognitive and Behavioural Differences
(2020-01)Cognitive behavioural correlates to bereavement-related mental health problems such a Prolonged Grief Disorder (PGD) and Posttraumatic Stress Disorder (PTSD) are of theoretical and clinical importance. Methods:Individuals ... -
Patterns in Weight and Physical Activity Tracking Data Preceding a Stop in Weight Monitoring: Observational Analysis
(2020-03)Background: Self-regulation for weight loss requires regular self-monitoring of weight, but the frequency of weight tracking commonly declines over time. Objective: This study aimed to investigate whether it is a decline ... -
Effective psychological treatment for PTSD changes the dynamics of specific large-‐scale brain networks
(2020-01)Very little is known about the role of effective cognitive therapy in reversing imbalances in brain activity after trauma. We hypothesised that exaggerated threat perception characteristic of p ... -
Sleep duration over 28 years, cognition, gray matter volume, and white matter microstructure: a prospective cohort study
(2020-01)Study Objectives To examine the association between sleep duration trajectories over 28 years and measures of cognition, gray matter volume, and white matter microstructure. We hypothesize that consistently meeting sleep ... -
What is the clinical value of mHealth for patients?
(2020-01)Despite growing interest from both patients and healthcare providers, there is little clinical guidance on how mobile apps should be utilized to add value to patient care. We categorize apps according to their functionality ... -
Effect of the NMDA receptor partial agonist, d-cycloserine, on emotional processing and autobiographical memory
(2020-04)Background: Studies suggest that d-cycloserine (DCS) may have antidepressant potential through its interaction with the glycine site of the N-Methyl-D-aspartate receptor (NMDAR); however clinical evidence of DCS’s efficacy ... -
Transient spectral events in resting state MEG predict individual task responses
(2020-07)Even in response to simple tasks such as hand movement, human brain activity shows remarkable inter-subject variability. Recently, it has been shown that individual spatial variability in fMRI task responses can be ... -
Translating the promise of 5HT4 receptor agonists for the treatment of depression
(2020-02)Animal experimental studies suggest that 5-HT4 receptor activation holds promise as a novel target for the treatment of depression and cognitive impairment. 5-HT4 receptors are postsynaptic receptors that are located in ... -
Cognitive Performance, Quality and Quantity of Movement Reflect Psychological Symptoms in Adolescents
(2020-05)The presentation of unhealthy psychological symptoms are rising sharply in adolescents. Detrimental lifestyle behaviours are proposed as both possible causes and consequences. This study set out to compare selected ...