Conditions, Lifestyle Factors & Interventions: Recent submissions
Now showing items 321-340 of 910
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A service evaluation of short-term mentalisation based treatment for personality disorder
(2021-08)Background People with personality disorder experience long waiting times for access to psychological treatments, resulting from a limited availability of long-term psychotherapies and a paucity of evidence-based brief ... -
Multi-scale neural signatures of major depressive, anxiety, and stress-related disorders
(2021-07)The extent of shared and distinct neural mechanisms underlying major depressive disorder (MDD), anxiety and stress-related disorders is still unclear. We compared the neural signatures of these disorders in 5,405 UK Biobank ... -
Elevated iron concentration in putamen and cortical speech motor network in developmental stuttering.
(2021-07)Theoretical accounts of developmental stuttering implicate dysfunctional cortico-striatalthalamo-cortical motor loops through the putamen. Analysis of conventional MRI brain scans in people who stutter has failed to yield ... -
Parenting an Autistic Child: Experiences of Parents with Significant Autistic Traits
(2021-07)Despite autism being highly heritable, this study is the first to investigate the experiences of parents of autistic children who have significant autistic traits themselves. Eight parents of autistic children with significant ... -
COVID-19 vaccine hesitancy in systemic sclerosis
(2021-07)In conclusion, our survey suggests that most patients with SSc have positive feelings towards COVID-19 vaccine, but uncertainties are present in a considerable proportion of cases. These results highlight the crucial ... -
Incidence and outcomes of eating disorders during the COVID-19 pandemic
(2021-07)There are concerns that eating disorders have become commoner during the coronavirus disease 2019 (COVID-19) pandemic. Using the electronic health records of 5.2 million people aged under 30, mostly in the USA, we show ... -
Extended follow-up of a short total diet replacement programme: results of the Doctor Referral of Overweight People to Low Energy total diet replacement Treatment (DROPLET) randomised controlled trial at 3 years
(2021-07)To test the long-term effectiveness of a total diet replacement programme (TDR) for routine treatment of obesity in a primary care setting. Methods This study was a pragmatic, two-arm, parallel-group, open-label, ... -
International Multicenter Analysis of Brain Structure Across Clinical Stages of Parkinson’s Disease
(2021-06)ABSTRACT: Background: Brain structure abnormalities throughout the course of Parkinson’s disease have yet to be fully elucidated. Objective: Using a multicenter approach and harmonized analysis methods, we aimed to shed ... -
The effect of overweight/obesity on diastolic function in children and adolescents: A meta-analysis
(2021-06)Left ventricular diastolic function (LVDF) is an important marker of early cardiovascular remodelling, which has not been well summarized in young people with overweight/ obesity. Weighted, random-effects regression was ... -
‘Do not attempt cardiopulmonary resuscitation’ (DNACPR)—difficulty in discussions with older medical inpatients and their families: a survey of hospital doctors
(2021-07)Objectives To determine, for doctors looking after older medical inpatients: (1) how difficult they find discussions about ‘do not attempt cardiopulmonary resuscitation’ (DNACPR); (2) whether difficulty is associated with ... -
Altered network stability in progressive supranuclear palsy
(2021-07)The clinical syndromes of Progressive Supranuclear Palsy (PSP) may be mediated by abnormal temporal dynamics of brain networks, due to the impact of atrophy, synapse loss and neurotransmitter deficits. We tested the ... -
Delineating between-subject heterogeneity in alpha networks with Spatio-Spectral Eigenmodes
(2021-10)Between subject variability in the spatial and spectral structure of oscillatory networks can be highly informative but poses a considerable analytic challenge. Here, we describe a data-driven modal decomposition of a ... -
Does raising heart rate prior to a behavioural test enhance learning in cognitive therapy for anxiety? An experimental test for the treatment of fear of heights using virtual reality
(2021-07)A key clinical issue is how to maximise the belief change central to cognitive therapy. Physiological arousal is a key internal cue confirming threat beliefs in anxiety disorders. Deeper extinction of anxiety may occur if ... -
Study protocol for a randomised placebo-controlled trial of pramipexole in addition to mood stabilisers for patients with treatment resistant bipolar depression (the PAX-BD study)
(2021-07)Treatment Resistant Bipolar Depression (TRBD) is a major contributor to the burden of disease associated with Bipolar Disorder (BD). Treatment options for people experiencing bipolar depression are limited to three ... -
Brain glutamate concentration in men with early psychosis: a magnetic resonance spectroscopy case–control study at 7 T
(2021-06)Abnormalities in glutamate neurotransmission are linked to psychotic symptoms and cognitive dysfunction in schizophrenia. magnetic resonance spectroscopy (MRS) provides an acceptable means of measuring glutamate in the ... -
Investigating the Mechanisms of Graded Sensorimotor Precision Training in Adults With Chronic Nonspecific Low Back Pain: Protocol for a Causal Mediation Analysis of the RESOLVE Trial
(2021-07)Chronic low back pain (CLBP) is a global health problem associated with an increasing burden on individuals, health care systems, and society. Common treatments for people with CLBP produce, on average, small short-term ... -
Behavioural sleep and circadian rhythm interventions in bipolar disorder: a systematic review of randomised controlled trials
(2021-07)Sleep and circadian rhythm disruptions are prominent symptoms of bipolar disorder (BD) and potential targets for adjunctive behavioural intervention. The aim of this systematic review was to appraise evidence from ... -
Does adjunctive digital CBT for insomnia improve clinical outcomes in an improving access to psychological therapies service?
(2021-09)Insomnia has a bidirectional relationship with broader mental health functioning, including anxiety and depression. Yet, poor sleep has historically been neglected as a specific treatment target in mental health programmes ... -
Results and Learning from the Healthy Outcomes for People with Eating Disorders (HOPE) New Care Model (Provider Collaborative) pilot: More investment required to address demand and capacity in adult community and inpatient eating disorder services
(2021-06)This article reports on pilot results and lessons learned from the HOPE New Care Model (Provider Collaborative). Pre-pandemic 12 beds were needed per million population. Demand for beds could be reduced by addressing the ... -
The NICE Evidence Standards Framework for digital health and care technologies – Developing and maintaining an innovative evidence framework with global impact
(2021-06)Objective: In 2018, the UK National Institute for Health and Care Excellence (NICE), in partnership with Public Health England, NHS England, NHS Improvement and others, developed an evidence standards framework (ESF) for ...