Browsing by Author "Goodwin, Guy M"
Now showing items 1-20 of 23
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Actigraphic patterns, impulsivity and moodinstability in bipolar disorder, borderlinepersonality disorder and healthy controls.
Goodwin, Guy M; Saunders, Kate E.A. (2020-01)Objectives:To differentiate the relation between the structure and timing of rest-activity patterns and symptoms of impulsivity and mood instability in bipolar disorder (BD), borderline personality disorder(BPD) and healthy ... -
Characterizing Affective Variability in Bipolar Disorder and Borderline Personality Disorder, and the Effects of Lithium, Using a Generative Model of Affect
Saunders, Kate E.A.; Harmer, Catherine J; Harrison, Paul J; Goodwin, Guy M; Geddes, John R; Browning, Michael (2022-02)The affective variability of Bipolar Disorder (BD) is thought to qualitatively differ from that of Borderline Personality Disorder (BPD), with changes in affect persisting for longer in BD. However, quantitative studies ... -
Comparative economic evaluation of quetiapine plus lamotrigine combination vs quetiapine monotherapy (and folic acid vs placebo) in patients with bipolar depression (cequel)
Geddes, John R; Gardiner, Alexandra; Rendell, Jennifer; Goodwin, Guy M; Simon, Judit (2018-12)Although not licensed for acute bipolar depression, lamotrigine has evidence for efficacy in trials and its use is recommended in guidelines. So far there had been no prospective health economic evaluation of its use. ... -
The costs of bipolar disorder in the United Kingdom
Simon, Judit; Goodwin, Guy M; Geddes, John R (2021-09)Objectives: To estimate the individual cost and population-level economic burden of Bipolar Disorder (BD), and explore the impact of clinical and sociodemographic factors on costs in the United Kingdom. Methods: Annual ... -
Do environmental risk factors for the development of psychosis distribute differently across dimensionally assessed psychotic experiences?
Johns, Louise; Goodwin, Guy M (2021-04)Psychotic experiences (PE) are associated with poorer functioning, higher distress and the onset of serious mental illness. Environmental exposures (e.g. childhood abuse) are associated with the development of PE. However, ... -
Effectiveness of maintenance therapy of lithium vs other mood stabilizers in monotherapy and in combinations: A systematic review of evidence from observational studies
Geddes, John R; Goodwin, Guy M (2018-02)Objectives: For the first time to present a systematic review of observational studies on the efficiency of lithium monotherapy in comparison with other maintenance mood stabilizers in monotherapy and in combination. Methods: ... -
The effects of improving sleep on mental health (OASIS): a randomised controlled trial with mediation analysis
Freeman, Daniel; Sheaves, Bryony; Goodwin, Guy M (2017-09-06)Summary: Background Sleep difficulties might be a contributory causal factor in the occurrence of mental health problems. If this is true, improving sleep should benefit psychological health. We aimed to determine whether ... -
Efficacy of digital cognitive behavioral therapy for moderate to severe symptoms of generalized anxiety disorder: A randomized controlled trial
Saunders, Kate E.A.; Goodwin, Guy M (2020-07)Cognitive behavioral therapy (CBT) is an efficacious intervention for generalized anxiety disorder (GAD). Digital CBT may provide a scalable means of delivering CBT at a population level. We investigated the efficacy of a ... -
Experiences of remote mood and activity monitoring in bipolar disorder: a qualitative study
Saunders, Kate E.A.; Geddes, John R; Goodwin, Guy M (2017-01)Mobile technology enables high frequency mood monitoring and automated passive collection of date(e.g.actigraphy) from patients more efficiently and less intrusively than has previously been possible. Such techniques are ... -
The heartland of psychiatry, revisited
Goodwin, Guy M (2019-11)The role of doctors will undoubtedly evolve as knowledge, and perverse ignorance become more universally available to all via the internet. The role of the psychiatrist must be to relate real advances in understanding ... -
Identifying psychiatric diagnosis from missing mood data through the use of log-signature features
Goodwin, Guy M; Saunders, Kate E.A. (2022-11)The availability of mobile technologies has enabled the efficient collection of prospective longitudinal, ecologically valid self-reported clinical questionnaires from people with psychiatric diagnoses. These data streams ... -
Investigation of the impact of total sleep deprivation at home on the number of intrusive memories to an analogue trauma
Goodwin, Guy M (2019-02)Sleep enhances the consolidation of memory; however, this property of sleep may be detrimental in situations where memories of an event can lead to psychopathology, such as following a traumatic event. Intrusive memories ... -
A leaky umbrella has little value: evidence clearly indicates the serotonin system is implicated in depression
Browning, Michael; Goodwin, Guy M; McCutcheon, Robert A; Cowen, Philip J (2023-06)A recent “umbrella” review examined various biomarkers relating to the serotonin system, and concluded there was no consistent evidence implicating serotonin in the pathophysiology of depression. We present reasons for why ... -
Mood Homeostasis, Low Mood, and History of Depression in 2 Large Population Samples
Saunders, Kate E.A.; Goodwin, Guy M (2020-04)Importance Existing therapeutic options are insufficient to tackle the disease burden of depression, and new treatments are sorely needed. Defining new psychotherapeutic targets is challenging given the paucity of coherent ... -
Patient fibroblast circadian rhythms predict lithium sensitivity in bipolar disorder
Cipriani, Andrea; Attenburrow, Mary Jane; Harrison, Paul J; Goodwin, Guy M (2020-05)Bipolar disorder is a chronic neuropsychiatric condition associated with mood instability, where patients present significant sleep and circadian rhythm abnormalities. Currently, the pathophysiology of bipolar disorder ... -
Plasma glutathione suggests oxidative stress is equally present in early- and late- onset bipolar disorder
Singh, Nisha; McMahon, Hannah; Bilderbeck, Amy; Reed, Zoe E; Tunbridge, Elizabeth; Brett, Daniel; Geddes, John R; Goodwin, Guy M (2018-03)We previously demonstrated oxidative stress in bipolar patients and a relationship between the age of illness onset and total glutathione, a principal antioxi- dant. In this study, we sought to replicate these findings ... -
Predicting Treatment Response to Antidepressant Medication Using Early Changes in Emotional Processing.
Browning, Michael; Goodwin, Guy M; Harmer, Catherine J (2019-01)Antidepressants must be taken for weeks before response can be assessed with many patients not responding to the first medication prescribed. This often results in long delays before effective treatment is started. ... -
A signature-based machine learning model for distinguishing bipolar disorder and borderline personality disorder
Goodwin, Guy M; Geddes, John R; Saunders, Kate E.A. (2018)Mobile technologies offer new opportunities for prospective, high resolution monitoring of long-term health conditions. The opportunities seem of particular promise in psychiatry where diagnoses often rely on retrospective and ... -
Smoking and the risk for bipolar disorder: evidence from a bidirectional Mendelian randomisation study
Goodwin, Guy M (2019-09)Background:There is increasing evidence that smoking is a risk factor for severe mental illness, including bipolar disorder. Conversely, patients with bipolar disorder might smoke more (often) as a result of the psychiatric ... -
The True Colours Remote Symptom Monitoring System: A Decade of Evolution
Geddes, John R; Goodwin, Guy M; Saunders, Kate E.A.; Mackay, Clare; Attenburrow, Mary Jane (2020-01)The True Colours remote mood monitoring system was developed over a decade ago by researchers, psychiatrists, and software engineers at the University of Oxford to allow patients to report on a range of symptoms via text ...