Browsing by Author "Godlewska, Beata R"
Now showing items 1-12 of 12
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Brain glutamate concentration in men with early psychosis: a magnetic resonance spectroscopy case–control study at 7 T
Godlewska, Beata R; Lennox, Belinda; Cowen, Philip J (2021-06)Abnormalities in glutamate neurotransmission are linked to psychotic symptoms and cognitive dysfunction in schizophrenia. magnetic resonance spectroscopy (MRS) provides an acceptable means of measuring glutamate in the ... -
Changes in brain Glx in depressed bipolar patients treated with lamotrigine: A proton MRS study
Godlewska, Beata R; Masakai, Charles; Bargiotas, Theodoras; Cowen, Philip J (2019-03)Background Lamotrigine is a useful treatment in bipolar depression but requires several weeks of dose titration before its clinical effects can be assessed. Animal experimental studies suggest that lamotrigine lowers ... -
Cognitive neuropsychological theory of antidepressant action: a modern-day approach to depression and its treatment
Godlewska, Beata R; Harmer, Catherine J (2020-01)Depression is a leading cause of disability worldwide and improving its treatment is a core research priority for future programmes. A change in the view of psychological and biological processes, from seeing them as ... -
Effects of escitalopram therapy on functional brain controllability in major depressive disorder
Godlewska, Beata R (2022-04)Antidepressant drugs are the mainstay of treatment for patients with major depressive disorders (MDD). Given the critical role of the underlying neural control mechanism in the physiopathology of depression, this study ... -
Functional Connectivity between Task-Positive Networks and the Left Precuneus as a Biomarker of Response to Lamotrigine in Bipolar Depression: A Pilot Study
Godlewska, Beata R (2021-06)Treatment of bipolar depression poses a significant clinical challenge. Lamotrigine is one of a few efficacious drugs, however, it needs to be titrated very slowly and response can only be assessed after 10–12 weeks. With ... -
Measuring Disturbance of the Endocannabinoid System in Psychosis A Systematic Review and Meta-analysis
Cipriani, Andrea; Lennox, Belinda; Godlewska, Beata R (2019-06)Importance: The endocannabinoid system (ECS) is a lipid-based endogenous signaling system. Its relevance to psychosis is through the association between cannabis use and the onset and course of illness and through the ... -
A phase 2a randomised, double-blind, placebo-controlled, parallel-group, add-on clinical trial of ebselen (SPI-1005) as a novel treatment for mania or hypomania.
Sharpley, Ann L; Williams, Clare; Holder, Adele A; Godlewska, Beata R; Macdonald, Orla; Cowen, Philip J (2020-09)Rationale Lithium is an effective prophylactic and anti-manic treatment in bipolar disorder; however, its use is declining through perceived poor tolerance and toxicity. Lithium inhibits inositol monophosphatase (IMPase), ... -
Predicting Antidepressant Treatment Response Using Functional Brain Controllability Analysis
Godlewska, Beata R (2023-03)Introduction: For decades, predicting response to the antidepressant medication has been a critical unmet need in depression treatment in clinic, and a technical challenge in depression research. Methods: In this study, ... -
Predicting treatment response in depression: the role of anterior cingulate cortex
Godlewska, Beata R; Browning, Michael; Cowen, Philip J; Harmer, Catherine J (2018)Background: Identification of biomarkers predicting therapeutic outcome to antidepressant treatment is one of the most important tasks in current research because it may transform the lengthy process of finding the right ... -
Resting state functional connectivity patterns as biomarkers of treatment response to escitalopram in patients with major depressive disorder
Harmer, Catherine J; Godlewska, Beata R (2021-09)With no available response biomarkers, matching an appropriate antidepressant to an individual can be a lengthy process. Improving understanding of processes underlying treatment responsivity in depression is crucial for ... -
Stress, inflammation and hippocampal subfields in depression: A 7 Tesla MRI Study
Cowen, Philip J; Godlewska, Beata R (2020-02)Experiencing stressful events throughout one’s life, particularly childhood trauma, increases the likelihood of being diagnosed with Major Depressive Disorder (MDD). Raised levels of cortisol, and markers of inflammation ... -
Translating the promise of 5HT4 receptor agonists for the treatment of depression
Murphy, Susannah E; De Cates, Angharad N; Gillespie, Amy L; Godlewska, Beata R; Scaife, Jessica; Wright, Lucy C; Cowen, Philip J; Harmer, Catherine J (2020-02)Animal experimental studies suggest that 5-HT4 receptor activation holds promise as a novel target for the treatment of depression and cognitive impairment. 5-HT4 receptors are postsynaptic receptors that are located in ...