Browsing by Author "Dahoun, Tarik"
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Chronic psychosocial stressors are associated with alterations in salience processing and corticostriatal connectivity.
Dahoun, Tarik (2018-12-17)Psychosocial stressors including childhood adversity, migration, and living in an urban environment, have been associated with several psychiatric disorders, including psychotic disorders. The neural and psychological ... -
Disrupted‐in‐schizophrenia 1 functional polymorphisms and D2/D3 receptor availability: A [11C]‐(+)‐PHNO imaging study
Dahoun, Tarik (2019-07)The disrupted‐in‐schizophrenia 1 (DISC1) protein has been implicated in a range of biological mechanisms underlying chronic mental disorders such as schizophrenia. Schizophrenia is associated with abnormal striatal dopamine ... -
The effect of a genetic variant at the schizophrenia associated AS3MT/BORCS7 locus on striatal dopamine function: A PET imaging study
Dahoun, Tarik (2019)One of the most statistically significant loci to result from large-scale GWAS of schizophrenia is 10q24.32. However, it is still unclear how this locus is involved in the pathoaetiology of schizophrenia. The hypothesis ... -
The effect of the DISC1 Ser704Cys polymorphism on striatal dopamine synthesis capacity: an [18F]-DOPA PET study
Dahoun, Tarik (2018-06)Whilst the role of the Disrupted-in-Schizophrenia 1 (DISC1) gene in the aetiology of major mental illnesses is debated, the characterisation of its function lends it credibility as a candidate. A key aspect of this functional ... -
Mesolimbic Dopamine Function is Related to Salience Network Connectivity: An Integrative PET and MR Study
Dahoun, Tarik (2018-09-29)A wide range of neuropsychiatric disorders from schizophrenia to drug addiction involve abnormalities in both the mesolimbic dopamine system and the cortical salience network. Both systems play a key role in the detection ...