Browsing by Author "Cowen, Philip J"
Now showing items 1-20 of 29
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3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for post-traumatic stress disorder in service personnel
Cipriani, Andrea; Cowen, Philip J (2018-06)Comment: This current study describes the therapeutic use of MDMA by committed experts in a specialised setting in a small group of participants, most of whom self-referred for the trial. The unmet need for better PTSD ... -
Acute neural effects of fluoxetine on emotional regulation in depressed adolescents
Capitao, Liliana; Chapman, Robert; Wright, Lucy C; Murphy, Susannah E; James, Anthony; Cowen, Philip J; Harmer, Catherine J (2022-05)Adolescent major depressive disorder (MDD) is associated with disrupted processing of emotional stimuli and difficulties in cognitive reappraisal. Little is known however about how current pharmacotherapies act to modulate ... -
Adaptive learning from outcome contingencies in eating-disorder risk groups
Pike, Alexandra C; Sharpley, Ann L; Park, Rebecca J; Cowen, Philip J; Browning, Michael; Pulcu, Erdem (2022-07)Eating disorders are characterised by altered eating patterns alongside overvaluation of body weight or shape, and have relatively low rates of successful treatment and recovery. Notably, cognitive inflexibility has been ... -
Brain glutamate concentration in men with early psychosis: a magnetic resonance spectroscopy case–control study at 7 T
Godlewska, Beata R; Lennox, Belinda; Cowen, Philip J (2021-06)Abnormalities in glutamate neurotransmission are linked to psychotic symptoms and cognitive dysfunction in schizophrenia. magnetic resonance spectroscopy (MRS) provides an acceptable means of measuring glutamate in the ... -
Changes in brain Glx in depressed bipolar patients treated with lamotrigine: A proton MRS study
Godlewska, Beata R; Masakai, Charles; Bargiotas, Theodoras; Cowen, Philip J (2019-03)Background Lamotrigine is a useful treatment in bipolar depression but requires several weeks of dose titration before its clinical effects can be assessed. Animal experimental studies suggest that lamotrigine lowers ... -
Comparative effects of pharmacological interventions for the acute and long-term management of insomnia disorder in adults: a systematic review and network meta-analysis
De Crescenzo, Franco; Ostinelli, Edoardo; Kurtulmus, Ayse; Tomlinson, Anneka; Quested, Digby J; Cowen, Philip J; Efthimiou, Orestis; Cipriani, Andrea (2022-07)Background: Behavioural, cognitive, and pharmacological interventions can all be effective for insomnia. However, because of inadequate resources, medications are more frequently used worldwide. We aimed to estimate the ... -
Déjà-vu? Neural and behavioural effects of the 5-HT 4 receptor agonist, prucalopride, in a hippocampal-dependent memory task
De Cates, Angharad N; Wright, Lucy C; Gibson, Daisy; Cowen, Philip J; Harmer, Catherine J; Murphy, Susannah E (2021-10)Cognitive deficits commonly accompany psychiatric disorders but are often underrecognised, and difficult to treat. The 5-HT4 receptor is a promising potential treatment target for cognitive impairment because in animal ... -
A Dissociation of the Acute Effects of Bupropion on Positive Emotional Processing and Reward Processing in Healthy Volunteers
Walsh, Annabel E L; Browning, Michael; Cowen, Philip J; Harmer, Catherine J (2018-10)Background: Previous research indicates that antidepressants can restore the balance between negative and positive emotional processing early in treatment, indicating a role of this effect in later mood improvement. However, ... -
Effect of the NMDA receptor partial agonist, d-cycloserine, on emotional processing and autobiographical memory
Harmer, Catherine J; Cowen, Philip J (2020-04)Background: Studies suggest that d-cycloserine (DCS) may have antidepressant potential through its interaction with the glycine site of the N-Methyl-D-aspartate receptor (NMDAR); however clinical evidence of DCS’s efficacy ... -
An Experimental Medicine Investigation of the Effects of Subacute Pramipexole Treatment on Emotional Information Processing in Healthy Volunteers
Cowen, Philip J; Harmer, Catherine J; Browning, Michael; Halahakoon, Don Chamith (2021-08)Treatment with the dopamine D2/D3 receptor agonist pramipexole has demonstrated promising clinical effects in patients with depression. However, the mechanisms through which pramipexole might alleviate depressive symptoms ... -
An Experimental Medicine Investigation of the Effects of Subacute Pramipexole Treatment on Emotional Information Processing in Healthy Volunteers
Halahakoon, Don Chamith; Browning, Michael; Cowen, Philip J; Harmer, Catherine J (2021-08)Treatment with the dopamine D2/D3 receptor agonist pramipexole has demonstrated promising clinical effects in patients with depression. However, the mechanisms through which pramipexole might alleviate depressive symptoms ... -
Fifty years on: Serotonin and depression
Cowen, Philip J; Browning, Michael (2023-03)It has been over 50 years since the original serotonin hypothesis was proposed by the British Psychiatrist Alec Coppen. Recently, some authors have questioned the validity of the hypothesis. In this narrative review, we ... -
The knowns and unknowns of SSRI treatment in young people with depression and anxiety: efficacy, predictors, and mechanisms of action
Murphy, Susannah E; Capitao, Liliana; Cowen, Philip J; Harmer, Catherine J (2021-08)The use of SSRIs for the treatment of depression and anxiety in young people is increasing. However, the effects of SSRIs in adolescence, a time when there are substantial changes in neural, cognitive, and social functioning, ... -
A leaky umbrella has little value: evidence clearly indicates the serotonin system is implicated in depression
Browning, Michael; Goodwin, Guy M; McCutcheon, Robert A; Cowen, Philip J (2023-06)A recent “umbrella” review examined various biomarkers relating to the serotonin system, and concluded there was no consistent evidence implicating serotonin in the pathophysiology of depression. We present reasons for why ... -
Lithium modulates striatal reward anticipation and prediction error coding in healthy volunteers
Volman, Inge; Browning, Michael; Cowen, Philip J; Harmer, Catherine J (2020-10)Lithium is one of the most effective mood-stabilizing medications in bipolar disorder. This study was designed to test whether lithium administration may stabilize mood via effects on reward processing. It was hypothesized ... -
Neural effects of a single dose of fluoxetine on resting-state functional connectivity in adolescent depression
Capitao, Liliana; Chapman, Robert; Wright, Lucy C; Murphy, Susannah E; James, Anthony; Cowen, Philip J; Harmer, Catherine J (2020-11)Fluoxetine is commonly prescribed in adolescent depression, but the neural mechanisms underlying its action remain poorly understood. Here, we used resting-state functional magnetic resonance imaging to investigate the ... -
No antidepressant-like acute effects of bright light on emotional information processing in healthy volunteers
Harmer, Catherine J; Zghoul, Tarek; Cowen, Philip J (2021-11)Rationale: Bright light treatment (BLT) is an efficacious antidepressant intervention, but its mechanism of action is not well understood. Antidepressant drugs acutely affect how emotional information is processed, pushing ... -
No benefit from flexible titration above minimum licensed dose in prescribing antidepressants for major depression: systematic review
Cowen, Philip J; Cipriani, Andrea (2019-12)Background In fixed‐dose antidepressant trials, the lower range of the licensed dose achieves the optimal balance between efficacy and tolerability. Whether flexible upward titration while side‐effects permit provides ... -
An online experimental medicine trial on the effect of 28-day simvastatin administration on emotional processing, reward learning, working memory and salivary cortisol in healthy volunteers at risk for depression: OxSTEP protocol
Di Giorgi, Riccardo; Cowen, Philip J (2023-06)Background: Evidence suggests inflammation may be a key mechanism by which psychosocial stress, including loneliness, predisposes to depression. Observational and clinical studies have suggested simvastatin, with its ... -
A phase 2a randomised, double-blind, placebo-controlled, parallel-group, add-on clinical trial of ebselen (SPI-1005) as a novel treatment for mania or hypomania.
Sharpley, Ann L; Williams, Clare; Holder, Adele A; Godlewska, Beata R; Macdonald, Orla; Cowen, Philip J (2020-09)Rationale Lithium is an effective prophylactic and anti-manic treatment in bipolar disorder; however, its use is declining through perceived poor tolerance and toxicity. Lithium inhibits inositol monophosphatase (IMPase), ...