Browsing by Author "Broome, Matthew R."
Now showing items 1-6 of 6
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Antipsychotic medication versus psychological intervention versus a combination of both in adolescents with first-episode psychosis (MAPS): a multicentre, three-arm, randomised controlled pilot and feasibility study
Johns, Louise; Freeman, Daniel; Broome, Matthew R.; James, Anthony (2020-07)Background Evidence for the effectiveness of treatments in early-onset psychosis is sparse. Current guidance for the treatment of early-onset psychosis is mostly extrapolated from trials in adult populations. The UK ... -
Prefrontal GABA levels, hippocampal resting perfusion and the risk of psychosis
Broome, Matthew R. (2018-01-30)Preclinical models propose that the onset of psychosis is associated with hippocampal hyperactivity, thought to be driven by cortical GABAergic interneuron dysfunction and disinhibition of pyramidal neurons. Recent ... -
Psychological intervention, antipsychotic medication or a combined treatment for adolescents with a first episode of psychosis: the MAPS feasibility three-arm RCT
Broome, Matthew R.; Freeman, Daniel; Johns, Louise; James, Anthony; Maughan, Daniel L (2021-01)Background: When psychosis emerges in young people there is a risk of poorer outcomes, and access to evidence-based treatments is paramount. The current evidence base is limited. Antipsychotic medications show only a small ... -
Study protocol for a randomised controlled trial of CBT vs antipsychotics vs both in 14–18-year-olds: Managing Adolescent first episode Psychosis: a feasibility study (MAPS)
Broome, Matthew R.; Freeman, Daniel (2019-07)Background: Adolescent-onset psychosis is associated with more severe symptoms and poorer outcomes than adult-onset psychosis. The National Institute for Clinical Excellence (NICE) recommend that adolescents with first ... -
A web-based clinical decision tool to support treatment decision-making in psychiatry: a pilot focus group study with clinicians, patients and carers
Smith, Katharine A; Attenburrow, Mary Jane; Henshall, Catherine; Zlodre, Jakov; Kelly, Kathleen; Broome, Matthew R.; Shaw, Susan; Barrera, Alvaro; Molodynski, Andrew; Reid, Alastair; Geddes, John R; Cipriani, Andrea (2017)Background Treatment decision tools have been developed in many fields of medicine, including psychiatry, however benefits for patients have not been sustained once the support is withdrawn. We have developed a web-based ... -
Young People who Self Harm: a Prospective One-Year Follow-up Study
Broome, Matthew R. (2016-12)Purpose: To explore repetition, service provision and service engagement following presentation of young people to emergency services with self-harm. Methods: 969 patients who presented to accident and emergency services ...