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Now showing items 799-818 of 1185
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Point-of- care blood tests during home visits by out-of- hours primary care clinicians; a mixed methods evaluation of a service improvement
(2020-01)Objectives We aimed to evaluate test usage and patient and clinician experience following the introduction of point-of- care (POC) blood tests into a primary care out-of- hours service. Design A mixed methods service ... -
Polyunsaturated fatty acids metabolism, purine metabolism and inosine as potential independent diagnostic biomarkers for major depressive disorder in children and adolescents
(2018-04-20)Major depressive disorder (MDD) in children and adolescents is a recurrent and disabling condition globally but its pathophysiology remains poorly elucidated and there are limited effective treatments available. We performed ... -
Poor medical student welfare—a growing threat to healthcare
(2021-08)The events of the last year have highlighted the importance of healthcare systems and of those who work in them to the wellbeing and functioning of society. As SARS-CoV2 has swept around the world, touching every family ... -
Positive Behaviour Support and Forensic Mental Health Care
(2021)"This assignment reviews the evidence about Positive Behaviour Support (PBS) in forensic mental health settings. It discusses the benefits and challenges of using PBS in forensic settings, including: why PBS is a good fit, ... -
Postnatal depression in fathers: a quiet struggle?
(2020-11)The mental health of fathers is now receiving more attention as a part of a national policy designed to address mens' mental health. Fatherhood can be a challenging period in a man's life and some men are at risk of ... -
Potential benefits of a ketogenic diet to improve response and recovery from physical exertion in people with Myalgic encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A feasibility study
(2019-11)Background: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) affects approximately 250,000 people in the UK. The condition varies in severity causing long-term physical and cognitive fatigue which is not ... -
Potential Interventions for Preventing Pesticide Self-Poisoning by Restricting Access Through Vendors in Sri Lanka: A Study of Stakeholders' Views
(2018-06)Background: In South Asia, up to one in five individuals who use pesticides for self-harm purchase them immediately prior to the event. Aims: From reviewing the literature we proposed four interventions: (a) farmer ... -
The Power Threat Meaning Framework and the Climate and Ecological Crises
(2022-09)Climate change poses an existential threat to today’s and future generations. Within this context, important debates are taking place about the risk of individualising and de-contextualising both climate-related distress ... -
Pragmatic Randomised Controlled Trial of Guided Self-help Versus Individual Cognitive Behavioural Therapy with a Trauma Focus for Post-Traumatic Stress Disorder (RAPID)
(2022-10)Post-traumatic stress disorder (PTSD) is a common, disabling condition that can occur following major traumatic events. Typical symptoms include distressing reliving, avoidance of reminders, and feeling a current sense ... -
Pramipexole Enhances Reward Learning by Preserving Value Estimates
(2022-01)Background: Dopamine D2-like receptor agonists show promise as treatments for depression. They are thought to act by altering how individuals learn from rewarding experiences. However, the nature of these reward learning ... -
Pramipexole for the Treatment of Depression: Efficacy and Mechanisms
(2023-11)Dopaminergic mechanisms are a plausible treatment target for patients with clinical depression but are relatively underexplored in conventional antidepressant medications. There is continuing interest in the potential ... -
Pre-analytical error for three point of care venous blood testing platforms in acute ambulatory settings: A mixed methods service evaluation
(2020-02)Introduction Point of care blood testing to aid diagnosis is becoming increasingly common in acute ambulatory settings and enables timely investigation of a range of diagnostic markers. However, this testing allows scope ... -
Precision biomarkers for mood disorders based on brain imaging
(2020-10)Mood disorders are a global public health problem because of their high prevalence, chronicity, and recurrence throughout the lifespan as well as increased risk of mortality.123 They also impose a heavy economic burden on ... -
Predicting Antidepressant Treatment Response Using Functional Brain Controllability Analysis
(2023-03)Introduction: For decades, predicting response to the antidepressant medication has been a critical unmet need in depression treatment in clinic, and a technical challenge in depression research. Methods: In this study, ... -
Predicting clinical deterioration after initial assessment in out-of-hours primary care: a retrospective service evaluation
(2017-01)Background: Accurate assessment of the need for admission is challenging in out-of-hours (OOH) primary care. Understanding more about patient contacts where the decision to continue care in the community may have been ... -
Predicting motor, cognitive & functional impairment in Parkinson’s
(2019-07)Objective: We recently demonstrated that 998 features derived from a simple 7-minute smartphone test could distinguish between controls, people with Parkinson’s and people with idiopathic Rapid Eye Movement sleep behavior ... -
Predicting poor outcomes in children aged 1–12 with respiratory tract infections: A systematic review
(2021-04)Background Demand for NHS services is high and rising. In children respiratory tract infections (RTI) are the most common reason for consultation with primary care. Understanding which features are associated with good ... -
Predicting treatment effects in unipolar depression: A meta-review
(2020-08)There is increasing interest in clinical prediction models in psychiatry, which focus on developing multivariate algorithms to guide personalized diagnostic or management decisions. The main target of these models is the ... -
Predicting treatment response in depression: the role of anterior cingulate cortex
(2018)Background: Identification of biomarkers predicting therapeutic outcome to antidepressant treatment is one of the most important tasks in current research because it may transform the lengthy process of finding the right ... -
Predicting Treatment Response to Antidepressant Medication Using Early Changes in Emotional Processing.
(2019-01)Antidepressants must be taken for weeks before response can be assessed with many patients not responding to the first medication prescribed. This often results in long delays before effective treatment is started. ...